000			02789nam a2200277 4500
001			393394
090			_a393394
100			_a20150721d2013 y0pory50 ba
101			_aeng
200			_aComprehensive forensic toxicological analysis of designer drugs _bRecurso eletrónico _efinal technical report _fAnthony P. DeCaprio, W. Lee Hearn, Madeleine J. Swortwood
210			_a[Rockville, MD] _cNational Criminal Justice Reference Service (NCJRS) _d2013
215			_a1 CD-ROM _d12 cm
300			_aResearch report submitted to the U.S. National Institute of Justice, Office of Justice Programs. Ficheiro de 1,61 MB em formato PDF (53 p.).
330			_a«"Designer drugs" are analogs or derivatives of controlled substances that are sold on the street in an attempt to circumvent the legal restrictions placed on scheduled drugs. New designer drugs are constantly emerging onto the illicit drug market and it is often difficult to validate and maintain comprehensive analytical methods for accurate detection of these compounds. Chemical modifications in these substances can be very subtle, leading to virtually unlimited structural variation. As a consequence, there are many hundreds of such entities that have been identified to date. Generally, forensic toxicology labs utilize a screening method, such as immunoassay, for the presumptive identification of drugs of abuse. When a positive result occurs, confirmatory methods, such as gas chromatography (GC) or liquid chromatography (LC) coupled with mass spectrometry (MS), are required for more sensitive and specific qualitative and quantitative analyses. In recent years, the need to study the activities of these compounds in screening assays as well as to develop confirmatory techniques to detect them in biological specimens has been recognized. Designer drugs have been a major topic of concern in Europe for some time and this issue has also become increasingly important in the United States. (…). The present project included two primary tasks. Task 1 consisted of determination of the cross-reactivity of designer drugs in common commercially available immunoassays. Task 2 consisted of similar screening evaluation using a series of blind spiked serum samples, with comparison to screening results obtained using a validated LC-QQQ-MS method and highresolution LC-QTOF-MS analysis.»
606			_aDROGA SINTÉTICA _9320915
606			_aANÁLISE LABORATORIAL _9326721
606			_aESTUPEFACIENTE _9343050
606			_aTOXICOLOGIA _9263124
700			_aDECAPRIO _bAnthony P. _9357798
701			_aHEARN _bW. Lee _9114086
701			_aSWORTWOOD _bMadeleine J. _9357799
955			_xOferta