000			03012nam a2200241 4500
001			390403
090			_a390403
100			_a20110720d2011 y0pory50 ba
101			_aeng
200			_aAnalysis of cocaine analytes in human hair II _bRecurso eletrónico _eevaluation of different hair color and ethnicity types _efinal report _fJeri D. Ropero Miller, Peter R. Stout
210			_a[Research Triangle Park, NC] _ced. do a. _d2011
215			_a1 CD-ROM _d12 cm
300			_a"Research report [prepared by] RTI International submitted to the U.S. Department of Justice. NIJ Award No. 2008-DN-BX-K179". Ficheiro de 90 Mb em formato pdf (235 p.). Também disponível através de: https://www.ncjrs.gov/app/publications/Abstract.aspx?id=256586. Acedido a 20 de Julho de 2011.
330			_aList of acronyms. Executive summary. Statement of the problem. Research purpose. Research design and methods. Findings. Stage I: Collection and analysis of donor hair samples. Stage II: Characterization of collected hair by microscopy. Stage III: Surface contamination of hair with COC HCl powder. Stage IV: Decontamination of hair. Stage V: Characterization of decontaminated hair. Stage VI: Analysis of hair by LC-MS/MS. Stage VII: Analysis of wash fractions. Conclusions. 1. Introduction. 1.1 Background. 1.2 Statement of the problem. 1.3 Literature review. 1.3.1 Utility of hair testing for detection of drugs of abuse. 1.3.2 Factors that may contribute to hair color/ethnicity biases. 1.3.3 Results of previous RTI investigations supporting this study. 1.3.4 Contamination studies in the literature. 1.4 Rationale for the research. 2. Research design and methods. 2.1 Experimental design — contamination of hair with pharmaceutical cocaine. 2.1.1 Subject and sample collection criteria. 2.1.2 Morphological characterization of hair. 2.1.3 Reagents and analytes for contamination and decontamination. 2.1.4 Hair contamination and decontamination methods. 2.1.5 Analytical sample preparation. 2.1.6 LC-MS/MS analyses. 2.1.7 Analysis of specimens by reference laboratory. 2.1.8 Statistical analysis procedures. 2.1.9 Modifications to research design and rationale. 3. Results. 3.1 Evaluation of subject hair for study inclusion. 3.2 Morphological examination. 3.3 Validation of COC, BE, CE, and NCOC. 3.4 Analyte concentrations after decontamination. 3.4.1 Cocaine. 3.4.2 CE. 3.4.3 NCOC. 3.4.4 BE. 3.4.5 BE/COC Ratios. 3.4.6 Decision criteria. 3.4.7 Addition of wash criterion. 3.4.8 Parallel results study (RTI and Reference Laboratory). 3.5 Conclusions. 3.5.1 Implications for policy and practice. 3.5.2 Implications for further research. 5. References. 6. Dissemination of research findings. List of figures.
606			_aANÁLISE LABORATORIAL _9326721
606			_aANÁLISE DE CABELO _9343199
606			_aCOCAÍNA _9343373
700			_aMILLER _bJeri D. Ropero _9356599
701			_aSTOUT _bPeter R. _9356600
955			_xOferta