02825nam a2200181   4500001000700000100004100007101000800048200018100056210005000237215002000287300030400307330192000611606002702531606002402558606001402582700002702596701002002623390403  a20110720d2011       y0pory50      ba  aeng  aAnalysis of cocaine analytes in human hair IIbRecurso eletrónicoeevaluation of different hair color and ethnicity typesefinal reportfJeri D. Ropero Miller, Peter R. Stout  a[Research Triangle Park, NC]ced. do a.d2011  a1 CD-ROMd12 cm  a"Research report [prepared by] RTI International submitted to the U.S. Department of Justice. NIJ Award No. 2008-DN-BX-K179". Ficheiro de 90 Mb em formato pdf (235 p.). Também disponível através de: https://www.ncjrs.gov/app/publications/Abstract.aspx?id=256586. Acedido a 20 de Julho de 2011.  aList of acronyms. Executive summary. Statement of the problem. Research purpose. Research design and methods. Findings. Stage I: Collection and analysis of donor hair samples. Stage II: Characterization of collected hair by microscopy. Stage III: Surface contamination of hair with COC HCl powder. Stage IV: Decontamination of hair. Stage V: Characterization of decontaminated hair. Stage VI: Analysis of hair by LC-MS/MS. Stage VII: Analysis of wash fractions. Conclusions. 1. Introduction. 1.1 Background. 1.2 Statement of the problem. 1.3 Literature review. 1.3.1 Utility of hair testing for detection of drugs of abuse. 1.3.2 Factors that may contribute to hair color/ethnicity biases. 1.3.3 Results of previous RTI investigations supporting this study. 1.3.4 Contamination studies in the literature. 1.4 Rationale for the research. 2. Research design and methods. 2.1 Experimental design — contamination of hair with pharmaceutical cocaine. 2.1.1 Subject and sample collection criteria. 2.1.2 Morphological characterization of hair. 2.1.3 Reagents and analytes for contamination and decontamination. 2.1.4 Hair contamination and decontamination methods. 2.1.5 Analytical sample preparation. 2.1.6 LC-MS/MS analyses. 2.1.7 Analysis of specimens by reference laboratory. 2.1.8 Statistical analysis procedures. 2.1.9 Modifications to research design and rationale. 3. Results. 3.1 Evaluation of subject hair for study inclusion. 3.2 Morphological examination. 3.3 Validation of COC, BE, CE, and NCOC. 3.4 Analyte concentrations after decontamination. 3.4.1 Cocaine. 3.4.2 CE. 3.4.3 NCOC. 3.4.4 BE. 3.4.5 BE/COC Ratios. 3.4.6 Decision criteria. 3.4.7 Addition of wash criterion. 3.4.8 Parallel results study (RTI and Reference Laboratory). 3.5 Conclusions. 3.5.1 Implications for policy and practice. 3.5.2 Implications for further research. 5. References. 6. Dissemination of research findings. List of figures.  aANÁLISE LABORATORIAL  aANÁLISE DE CABELO  aCOCAÍNA  aMILLERbJeri D. Ropero  aSTOUTbPeter R.