Ficheiro de 4,68 MB em formato PDF (441 p.).

1. Introduction to Therapeutic Drug Monitoring. 2. Monitoring Free Drug Concentration. 3. Analytical Techniques for Measuring Concentrations of Therapeutic Drugs in Biological Fluids. 4. The Pre-Analytical Phase of Drug Testing: From Specimen Collection to Analysis. 5. Effect of Hemolysis, High Bilirubin, Lipemia, Paraproteins, and System Factors on Therapeutic Drug Monitoring. 6. Digoxin: So Many Interferences and How to Eliminate Them. 7. Interferences with Measurement of Anticonvulsants. 8. Pitfalls in Measuring Antidepressant Drugs. 9. Immunosuppressive Drugs: Pharmacokinetics, Preanalytic Variables, and Analytical Considerations. 10. Therapeutic Drug Monitoring in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. 11. Pharmacogenomics and Personalized Medicine: Issues and Methodology. 12. Interference of Heterophilic and Other Antibodies in Measurement of Therapeutic Drugs by Immunoassays. 13. Drug–Herb and Drug–Food Interactions: Impact on Therapeutic Drug Monitoring. 14. Toxic Element Testing with Clinical Specimens. 15. Alcohol Testing. 16. Introduction to Drugs of Abuse Testing. 17. Urinary Adulterants and Drugs of Abuse Testing. 18. Hair, Oral Fluid, Sweat, and Meconium Testing for Drugs of Abuse: Advantages and Pitfalls. 19. Abused and Designer Drugs and How They Escape Detection. 20. Interpretation of Amphetamines Screening and Confirmation Testing. 21. Clinical False-Positive Drug Test Results. 22. Providing Expert Witness for Alcohol and Positive Drugs of Abuse Test Results. Index.