Foreword. Acknowledgements. Introduction. The drugs - 1. Ecstasy: definition and classification; historical perspectives; dosage and route of administration; effects of ecstasy (physical effects; psychological effects; neurotoxicity). 2. Amphetamines: definition and classification; historical perspectives; dosage and route of administration; effects of amphetamines (physical effects; psychological effects; neurotoxicity). 3. LSD: definition and classification; historical perspectives; dosage and route of administration; effects of LSD (physical effects; psychological effects; neurotoxicity). New trends - 1. The social and cultural development of a new drug trend. 2. Gender issues. 3. Gay issues. 4. Commerce and the media. 5. Alcohol. 6. Poly-drug use. 7. Supply issues. The epidemiology of synthetic drugs - 1. Drug monitoring systems. 2. The prevalence of synthetic drug use in Europe. 3. Conclusion: rapid reporting systems. Demand reduction and synthetic drugs - 1. Demand reduction responses. 2. Prevention. 3. Public prevention activities. 4. Information, education and harm reduction. 5. Regulation, collaboration and conflict. 6. Guidelines and safer dancing. 7. Outreach, peer education and self-help. 8. Working with the scene. 9. Evaluation. 10. Conclusion: responses and interventions. Conclusion. Glossary. Timeline. References.